PerspectiveImmunology

A LoCK at the T cell dock

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Science  04 Jun 2021:
Vol. 372, Issue 6546, pp. 1038-1039
DOI: 10.1126/science.abj2937

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Summary

The stimulation of T cells with foreign or self-antigens plays a central role in the adaptive immune responses to infection and cancer but also in autoimmunity. T cells use a sophisticated molecular machinery to recognize and respond to cognate antigens. On page 1056 of this issue, Zareie et al. (1) examine the productive and unproductive engagement of the T cell receptor (TCR) with antigens by focusing on binding orientation. The polarity of the interaction affects recruitment of key signaling molecules to the TCR. This topology thus constrains T cell immune responses.

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