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Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain

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Science  11 Jun 2021:
Vol. 372, Issue 6547, pp. 1205-1209
DOI: 10.1126/science.abg8467

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Gliogenesis in the adult mouse brain

Neural stem cells in the adult mouse brain can generate both neurons and glia. Exactly where each stem cell is positioned can determine what type of neurons it generates. Delgado et al. show that neural stem cells are also choosy about what sorts of glia they make and when (see the Perspective by Baldwin and Silver). Injury or selective deletion of platelet-derived growth factor receptor β (PDGFRβ) from the stem cells kicked them into overdrive and revealed their selectivity with respect to gliogenesis. An unusual type of glial progenitor cell, intraventricular oligodendrocyte progenitors, are found nestled between the cilia of ependymal cells derived from tight clusters of PDGFRβ-expressing stem cells.

Science, abg8467, this issue p. 1205; see also abj1139, p. 1151

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