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Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

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Science  11 Jun 2021:
Vol. 372, Issue 6547, pp. 1224-1229
DOI: 10.1126/science.abe9985

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  • RE: Prediabetes

    Letter to the Editors

    Interesting work on clinical studies boosting NAD+ (Science June 11, 2021) is described by Yoshino et al (p. 1224) and summarized by Hepler et al (p. 1147). The studies were carried out on postmenopausal prediabetic women. The authors suggest that their findings might lead to a health supplement to prevent prediabetes.

    However, Science published a compelling report on the dubious existence of such a condition as prediabetes (Piller, Mar 7, 2019). The article also cited efforts by the American Diabetes Association to promote the acceptance of this condition even though supporting data was weak at best.

    It is unfortunate that neither Hepler or Yoshino acknowledged the controversial nature of the prediabetes diagnosis. I think the Science editors should have stepped in and required a comment on this.

    Blaise J. Arena
    Chicago
    AAAS member

    Competing Interests: None declared.

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