Research Article

Cerebrospinal fluid influx drives acute ischemic tissue swelling

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Science  30 Jan 2020:
eaax7171
DOI: 10.1126/science.aax7171

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History: 
  • Received for publication June 22, 2019
  • Resubmitted December 16, 2019
  • Accepted for publication January 17, 2020
  • .

Author Information

  1. Humberto Mestre1,2,*,
  2. Ting Du1,3,*,
  3. Amanda M. Sweeney1,
  4. Guojun Liu1,4,
  5. Andrew J. Samson5,
  6. Weiguo Peng5,
  7. Kristian Nygaard Mortensen5,
  8. Frederik Filip Stæger5,
  9. Peter A.R. Bork5,6,
  10. Logan Bashford7,
  11. Edna R. Toro7,
  12. Jeffrey Tithof7,
  13. Douglas H. Kelley7,
  14. John H. Thomas7,
  15. Poul G. Hjorth6,
  16. Erik A. Martens6,
  17. Rupal I. Mehta1,2,8,9,
  18. Orestes Solis8,
  19. Pablo Blinder10,11,
  20. David Kleinfeld12,13,
  21. Hajime Hirase5,14,
  22. Yuki Mori5,,
  23. Maiken Nedergaard1,5,
  1. 1Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
  2. 2Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.
  3. 3School of Pharmacy, China Medical University, Shenyang 110122, China.
  4. 4Department of Neurosurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
  5. 5Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  6. 6Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark.
  7. 7Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.
  8. 8Department of Pathology, Rush University, Chicago, IL 60612, USA.
  9. 9Rush Alzheimer’s Disease Center, Rush University, Chicago, IL 60612, USA.
  10. 10Neurobiology, Biochemistry and Biophysics School, George S. Wise Faculty of Life Sciences, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.
  11. 11Sagol School for Neuroscience, Tel Aviv University, 30 Haim Levanon St., Tel Aviv 69978, Israel.
  12. 12Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
  13. 13Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
  14. 14Laboratory of Neuron-Glia Circuitry, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  1. Corresponding author. Email: maiken_nedergaard{at}urmc.rochester.edu (M.N.); yuki.mori{at}sund.ku.dk (Y.M.)
  1. * These authors contributed equally to this work.

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