Research Article

CRISPR-engineered T cells in patients with refractory cancer

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Science  06 Feb 2020:
eaba7365
DOI: 10.1126/science.aba7365

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History: 
  • Received for publication January 3, 2020
  • Accepted for publication January 28, 2020
  • .

Author Information

  1. Edward A. Stadtmauer1,2,*,,
  2. Joseph A. Fraietta2,3,4,5,*,
  3. Megan M. Davis5,6,
  4. Adam D. Cohen1,2,
  5. Kristy L. Weber2,7,
  6. Eric Lancaster8,
  7. Patricia A. Mangan1,
  8. Irina Kulikovskaya5,
  9. Minnal Gupta5,
  10. Fang Chen5,
  11. Lifeng Tian5,
  12. Vanessa E. Gonzalez5,
  13. Jun Xu5,
  14. In-young Jung4,5,
  15. J. Joseph Melenhorst3,5,6,
  16. Gabriela Plesa5,
  17. Joanne Shea5,
  18. Tina Matlawski5,
  19. Amanda Cervini5,
  20. Avery L. Gaymon5,
  21. Stephanie Desjardins5,
  22. Anne Lamontagne5,
  23. January Salas-Mckee5,
  24. Andrew Fesnak5,6,
  25. Donald L. Siegel5,6,
  26. Bruce L. Levine5,6,
  27. Julie K. Jadlowsky5,
  28. Regina M. Young5,
  29. Anne Chew5,
  30. Wei-Ting Hwang9,
  31. Elizabeth O. Hexner1,2,
  32. Beatriz M. Carreno3,5,6,
  33. Christopher L. Nobles4,
  34. Frederic D. Bushman4,
  35. Kevin R. Parker10,
  36. Yanyan Qi11,
  37. Ansuman T. Satpathy10,11,
  38. Howard Y. Chang10,12,
  39. Yangbing Zhao5,6,
  40. Simon F. Lacey5,6,*,
  41. Carl H. June2,3,5,6,*,
  1. 1Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  2. 2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  3. 3Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  4. 4Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  5. 5Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  6. 6Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  7. 7Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  8. 8Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  9. 9Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  10. 10Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.
  11. 11Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  12. 12Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.
  1. Corresponding author. Email: edward.stadtmauer{at}pennmedicine.upenn.edu (E.A.S.); cjune{at}upenn.edu (C.H.J.)
  1. * These authors contributed equally to this work.

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