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Temporal integration of mitogen history in mother cells controls proliferation of daughter cells

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Science  02 Apr 2020:
eaay8241
DOI: 10.1126/science.aay8241

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Abstract

Multi-cellular organisms use mitogens to regulate cell proliferation, yet how fluctuating mitogenic signals are converted into proliferation-quiescence decisions is poorly understood. Here we combine live-cell imaging with temporally controlled perturbations to determine the timescale and mechanisms underlying the system. Contrary to the textbook model that cells only sense mitogen availability in G1, we find that mitogenic signaling is temporally integrated throughout the entire mother cell cycle, and even a one-hour lapse in mitogen signaling can influence cell proliferation over 12 hours later. Protein translation rates serve as the integrator that proportionally converts mitogen history into corresponding levels of Cyclin D in G2 phase of the mother cell, which controls the proliferation-quiescence decision in daughter cells, and thereby couples protein production with cell proliferation.

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