Research ArticleNEURODEVELOPMENT

A brain-wide atlas of synapses across the mouse lifespan

See allHide authors and affiliations

Science  11 Jun 2020:
eaba3163
DOI: 10.1126/science.aba3163

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Synapses connect neurons together to form the circuits of the brain and their molecular composition controls innate and learned behavior. We have analyzed the molecular and morphological diversity of five billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the lifespan. Expansion in synapse diversity produces differentiation of brain regions until early adulthood and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for lifespan transitions in intellectual ability, memory, and susceptibility to behavioral disorders.

View Full Text

Stay Connected to Science