Research Article

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

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Science  09 Sep 2020:
eabd9909
DOI: 10.1126/science.abd9909

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History: 
  • Received for publication July 24, 2020
  • Accepted for publication September 3, 2020
  • .

Author Information

  1. Longxing Cao1,2,
  2. Inna Goreshnik1,2,
  3. Brian Coventry1,2,3,
  4. James Brett Case4,
  5. Lauren Miller1,2,
  6. Lisa Kozodoy1,2,
  7. Rita E. Chen4,5,
  8. Lauren Carter1,2,
  9. Alexandra C. Walls1,
  10. Young-Jun Park1,
  11. Eva-Maria Strauch6,
  12. Lance Stewart1,2,
  13. Michael S. Diamond4,7,
  14. David Veesler1,
  15. David Baker1,2,8,*
  1. 1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  2. 2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  3. 3Molecular Engineering Graduate Program, University of Washington, Seattle, WA 98195, USA.
  4. 4Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  5. 5Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  6. 6Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA.
  7. 7The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA.
  8. 8Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
  1. *Corresponding author. E-mail: dabaker{at}uw.edu

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