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January 14, 2021
- A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols
  
  By Renhong Yan, Pingping Cao, Wenqi Song, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan
  
  Published Online14 Jan 2021 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb2224
  
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- Widespread haploid-biased gene expression enables sperm-level natural selection
  
  By Kunal Bhutani, Katherine Stansifer, Simina Ticau, Lazar Bojic, Alexandra-Chloé Villani, Joanna Slisz, Claudia M. Cremers, Christian Roy, Jerry Donovan, Brian Fiske, Robin C. Friedman
  
  Published Online14 Jan 2021 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb1723
  
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January 12, 2021
- Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
  
  By Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Lisa D. J. Schiffelers, Yonas M. Tesfamariam, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey, Sabine Normann, Jan M. P. Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L. Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A. Wilson, Matthias Geyer, Kerstin U. Ludwig, B. Martin Hällberg, Nicholas C. Wu, Florian I. Schmidt
  
  Published Online12 Jan 2021 Open Access
  
  DOI: 10.1126/science.abe6230
  
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- Immunological characteristics govern the transition of COVID-19 to endemicity
  
  By Jennie S. Lavine, Ottar N. Bjornstad, Rustom Antia
  
  Published Online12 Jan 2021 Open Access
  
  DOI: 10.1126/science.abe6522
  
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- Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice
  
  By Alexander A. Cohen, Priyanthi N. P. Gnanapragasam, Yu E. Lee, Pauline R. Hoffman, Susan Ou, Leesa M. Kakutani, Jennifer R. Keeffe, Hung-Jen Wu, Mark Howarth, Anthony P. West, Christopher O. Barnes, Michel C. Nussenzweig, Pamela J. Bjorkman
  
  Published Online12 Jan 2021 Open Access
  
  DOI: 10.1126/science.abf6840
  
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January 08, 2021
- Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK
  
  By Louis du Plessis, John T. McCrone, Alexander E. Zarebski, Verity Hill, Christopher Ruis, Bernardo Gutierrez, Jayna Raghwani, Jordan Ashworth, Rachel Colquhoun, Thomas R. Connor, Nuno R. Faria, Ben Jackson, Nicholas J. Loman, Áine O’Toole, Samuel M. Nicholls, Kris V. Parag, Emily Scher, Tetyana I. Vasylyeva, Erik M. Volz, Alexander Watts, Isaac I. Bogoch, Kamran Khan, COVID-19 Genomics UK (COG-UK) Consortium, David M. Aanensen, Moritz U. G. Kraemer, Andrew Rambaut, Oliver G. Pybus
  
  Published Online08 Jan 2021 Open Access
  
  DOI: 10.1126/science.abf2946
  
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January 07, 2021
- RNA stabilization by a poly(A) tail 3ʹ-end binding pocket and other modes of poly(A)-RNA interaction
  
  By Seyed-Fakhreddin Torabi, Anand T. Vaidya, Kazimierz T. Tycowski, Suzanne J. DeGregorio, Jimin Wang, Mei-Di Shu, Thomas A. Steitz, Joan A. Steitz
  
  Published Online07 Jan 2021 Full AccessRestricted Access
  
  DOI: 10.1126/science.abe6523
  
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- Characterization of a common progenitor pool of the epicardium and myocardium
  
  By Richard C. V. Tyser, Ximena Ibarra-Soria, Katie McDole, Satish A. Jayaram, Jonathan Godwin, Teun A. H. van den Brand, Antonio M. A. Miranda, Antonio Scialdone, Philipp J. Keller, John C. Marioni, Shankar Srinivas
  
  Published Online07 Jan 2021 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb2986
  
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January 06, 2021
- Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
  
  By Jennifer M. Dan, Jose Mateus, Yu Kato, Kathryn M. Hastie, Esther Dawen Yu, Caterina E. Faliti, Alba Grifoni, Sydney I. Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A. Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica Ollmann Saphire, Davey M. Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty
  
  Published Online06 Jan 2021 Open Access
  
  DOI: 10.1126/science.abf4063
  
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December 31, 2020
- In situ genome sequencing resolves DNA sequence and structure in intact biological samples
  
  By Andrew C. Payne, Zachary D. Chiang, Paul L. Reginato, Sarah M. Mangiameli, Evan M. Murray, Chun-Chen Yao, Styliani Markoulaki, Andrew S. Earl, Ajay S. Labade, Rudolf Jaenisch, George M. Church, Edward S. Boyden, Jason D. Buenrostro, Fei Chen
  
  Published Online31 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.aay3446
  
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December 23, 2020
- Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
  
  By Mads Delbo Larsen, Erik L. de Graaf, Myrthe E. Sonneveld, H. Rosina Plomp, Jan Nouta, Willianne Hoepel, Hung-Jen Chen, Federica Linty, Remco Visser, Maximilian Brinkhaus, Tonći Šuštić, Steven W. de Taeye, Arthur E. H. Bentlage, Suvi Toivonen, Carolien A. M. Koeleman, Susanna Sainio, Neeltje A. Kootstra, Philip J.M. Brouwer, Chiara Elisabeth Geyer, Ninotska I. L. Derksen, Gertjan Wolbink, Menno de Winther, Rogier W. Sanders, Marit J. van Gils, Sanne de Bruin, Alexander P. J. Vlaar, Amsterdam UMC COVID-19 biobank study group, Theo Rispens, Jeroen den Dunnen, Hans L. Zaaijer, Manfred Wuhrer, C. Ellen van der Schoot, Gestur Vidarsson
  
  Published Online23 Dec 2020 Open Access
  
  DOI: 10.1126/science.abc8378
  
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December 17, 2020
- Microbial single-cell RNA sequencing by split-pool barcoding
  
  By Anna Kuchina, Leandra M. Brettner, Luana Paleologu, Charles M. Roco, Alexander B. Rosenberg, Alberto Carignano, Ryan Kibler, Matthew Hirano, R. William DePaolo, Georg Seelig
  
  Published Online17 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.aba5257
  
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- HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
  
  By Haiyang Yu, Shan Lu, Kelsey Gasior, Digvijay Singh, Sonia Vazquez-Sanchez, Olga Tapia, Divek Toprani, Melinda S. Beccari, John R. Yates III, Sandrine Da Cruz, Jay M. Newby, Miguel Lafarga, Amy S. Gladfelter, Elizabeth Villa, Don W. Cleveland
  
  Published Online17 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb4309
  
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December 15, 2020
- Inferring the effectiveness of government interventions against COVID-19
  
  By Jan M. Brauner, Sören Mindermann, Mrinank Sharma, David Johnston, John Salvatier, Tomáš Gavenčiak, Anna B. Stephenson, Gavin Leech, George Altman, Vladimir Mikulik, Alexander John Norman, Joshua Teperowski Monrad, Tamay Besiroglu, Hong Ge, Meghan A. Hartwick, Yee Whye Teh, Leonid Chindelevitch, Yarin Gal, Jan Kulveit
  
  Published Online15 Dec 2020 Open Access
  
  DOI: 10.1126/science.abd9338
  
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December 10, 2020
- Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
  
  By Jacob E. Lemieux, Katherine J. Siddle, Bennett M. Shaw, Christine Loreth, Stephen F. Schaffner, Adrianne Gladden-Young, Gordon Adams, Timelia Fink, Christopher H. Tomkins-Tinch, Lydia A. Krasilnikova, Katherine C. DeRuff, Melissa Rudy, Matthew R. Bauer, Kim A. Lagerborg, Erica Normandin, Sinéad B. Chapman, Steven K. Reilly, Melis N. Anahtar, Aaron E. Lin, Amber Carter, Cameron Myhrvold, Molly E. Kemball, Sushma Chaluvadi, Caroline Cusick, Katelyn Flowers, Anna Neumann, Felecia Cerrato, Maha Farhat, Damien Slater, Jason B. Harris, John A. Branda, David Hooper, Jessie M. Gaeta, Travis P. Baggett, James O’Connell, Andreas Gnirke, Tami D. Lieberman, Anthony Philippakis, Meagan Burns, Catherine M. Brown, Jeremy Luban, Edward T. Ryan, Sarah E. Turbett, Regina C. LaRocque, William P. Hanage, Glen R. Gallagher, Lawrence C. Madoff, Sandra Smole, Virginia M. Pierce, Eric Rosenberg, Pardis C. Sabeti, Daniel J. Park, Bronwyn L. MacInnis
  
  Published Online10 Dec 2020 Open Access
  
  DOI: 10.1126/science.abe3261
  
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- Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
  
  By Erez N. Baruch, Ilan Youngster, Guy Ben-Betzalel, Rona Ortenberg, Adi Lahat, Lior Katz, Katerina Adler, Daniela Dick-Necula, Stephen Raskin, Naamah Bloch, Daniil Rotin, Liat Anafi, Camila Avivi, Jenny Melnichenko, Yael Steinberg-Silman, Ronac Mamtani, Hagit Harati, Nethanel Asher, Ronnie Shapira-Frommer, Tal Brosh-Nissimov, Yael Eshet, Shira Ben-Simon, Oren Ziv, Md Abdul Wadud Khan, Moran Amit, Nadim J. Ajami, Iris Barshack, Jacob Schachter, Jennifer A. Wargo, Omry Koren, Gal Markel, Ben Boursi
  
  Published Online10 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb5920
  
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- Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease
  
  By Christina V. Theodoris, Ping Zhou, Lei Liu, Yu Zhang, Tomohiro Nishino, Yu Huang, Aleksandra Kostina, Sanjeev S. Ranade, Casey A. Gifford, Vladimir Uspenskiy, Anna Malaschicheva, Sheng Ding, Deepak Srivastava
  
  Published Online10 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abd0724
  
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- Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
  
  By A. R. Palla, M. Ravichandran, Y. X. Wang, L. Alexandrova, A. V. Yang, P. Kraft, C. A. Holbrook, C. M. Schürch, A. T. V. Ho, H. M. Blau
  
  Published Online10 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abc8059
  
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December 03, 2020
- Postnatal connectomic development of inhibition in mouse barrel cortex
  
  By Anjali Gour, Kevin M. Boergens, Natalie Heike, Yunfeng Hua, Philip Laserstein, Kun Song, Moritz Helmstaedter
  
  Published Online03 Dec 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abb4534
  
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November 26, 2020
- Human NLRP1 is a sensor for double-stranded RNA
  
  By Stefan Bauernfried, Matthias J. Scherr, Andreas Pichlmair, Karl E. Duderstadt, Veit Hornung
  
  Published Online26 Nov 2020 Full AccessRestricted Access
  
  DOI: 10.1126/science.abd0811
  
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January 14, 2021

January 12, 2021

January 08, 2021

January 07, 2021

January 06, 2021

December 31, 2020

December 23, 2020

December 17, 2020

December 15, 2020

December 10, 2020

December 03, 2020

November 26, 2020

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