Supplemental Data


Abstract
Full Text
Autosomal Dominant Mutations Affecting X Inactivation Choice in the Mouse
Ivona Percec, Robert M. Plenge, Joseph H. Nadeau, Marisa S. Bartolomei, and Huntington F. Willard

Supplementary Material

Supplemental Figure 1. Genome scan of pedigree 24.21 demonstrates linkage of the mutant phenotype to chromosome 15. Five affected G4 and G5females were genotyped with microsatellite markers spaced evenly throughout the genome with a maximum spacing of 30 cM (36). The location of the markers is designated by arrowheads on the left of each chromosome. Genotypes for the five individual females are represented as vertical bars 1 through 5 for each chromosome. Unfilled regions of the bars represent wildtype genotypes (i.e. from the nonmutagenized parent), while filled regions represent BALB/cByJ alleles inherited from the ENU-treated founder male. The probability that the ENU-treated alleles were inherited in the proximal region of chromosome 15 by chance is P ? 0.004. Alleles from the ENU-treated male were not observed on chromosomes 4, 6, 7, 8, 11, 16, 17, 18 (29).


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