Supporting Online Material

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones, Xiaosong Zhang, D. Williams Parsons, Jimmy Cheng-Ho Lin, Rebecca J. Leary, Philipp Angenendt, Parminder Mankoo, Hannah Carter, Hirohiko Kamiyama, Antonio Jimeno, Seung-Mo Hong, Baojin Fu, Ming-Tseh Lin, Eric S. Calhoun, Mihoko Kamiyama, Kimberly Walter, Tatiana Nikolskaya, Yuri Nikolsky, James Hartigan, Douglas R. Smith, Manuel Hidalgo, Steven D. Leach, Alison P. Klein, Elizabeth M. Jaffee, Michael Goggins, Anirban Maitra, Christine Iacobuzio-Donahue, James R. Eshleman, Scott E. Kern, Ralph H. Hruban, Rachel Karchin, Nickolas Papadopoulos, Giovanni Parmigiani, Bert Vogelstein,* Victor E. Velculescu, Kenneth W. Kinzler

Supporting Online Material

This supplement contains:
Materials and Methods
Fig. S1

Corrected 25 September 2008:
Minor revisions were made to the Materials and Methods to improve clarity. In addition, Table S3 (in the zipped file) was revised. A column providing further integration between the mutational and expression data was added.
The original version can be found here

This file is in Adobe Acrobat PDF format.

Other Supporting Online Material for this manuscript includes the following: (available at
Tables S1 to S9. Supporting tables, in Microsoft Excel and tab-delimited ASCII format; brief descriptions appear in main SOM PDF file. File is packaged as a compressed archive, in *.zip format; users should download the compressed file to their machine and decompress the file on their local hard drive, using the instructions below.

Tables Corrected 25 September 2008
The original version can be found here

Tables Corrected 27 October 2008
An error in Table S9 has been corrected. For greater clarity, a separate worksheet (9B) with lines for each SAGE tag of each gene (rather than just the summed SAGE tags for each gene) has also been added to Table S3. The first revision can be found here

Instructions for downloading and decompressing files:

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  2. Save the compressed archive to the temporary folder you created, using the links above.
  3. Decompress the compressed file in the temporary folder using decompression software such as WinZip (Windows; or StuffIt Expander (Windows and Mac;

Excel files can be opened and viewed using Microsoft Excel, the spreadsheet module of the freely downloadable Open Office suite, or the freely downloadable Excel Viewer available from Microsoft.