Supplementary Materials

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

Brett E. Johnson, Tali Mazor, Chibo Hong, Michael Barnes, Koki Aihara, Cory Y. McLean, Shaun D. Fouse, Shogo Yamamoto, Hiroki Ueda, Kenji Tatsuno, Saurabh Asthana, Llewellyn E. Jalbert, Sarah J. Nelson, Andrew W. Bollen, W. Clay Gustafson, Elise Charron, William A. Weiss, Ivan V. Smirnov, Jun S. Song, Adam B. Olshen, Soonmee Cha, Yongjun Zhao, Richard A. Moore, Andrew J. Mungall, Steven J. M. Jones, Martin Hirst, Marco A. Marra, Nobuhito Saito, Hiroyuki Aburatani, Akitake Mukasa, Mitchel S. Berger, Susan M. Chang, Barry S. Taylor, Joseph F. Costello

Materials/Methods, Supporting Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S14
  • Captions for tables S1 to S7
  • References
Tables S1 to S7
Table S1 (separate file)
Summary of the clinical features, treatment history and molecular features of each tumor
in the cohort.

Table S2 (separate file)
Quality control metrics for exomes sequenced in this study.

Table S3 (separate file)
A list of somatic mutations identified in this study along with RNA-seq and Sanger
validation status.

Table S4 (separate file)
Patterns of genetic evolution between initial and recurrent gliomas.

Table S5 (separate file)
A list of all mutations included in the phylogenetic trees in Figure 2 and the
phylogenetic tree branch on which each mutation lies.

Table S6 (separate file)
Mutation rates in each tumor at each dinucleotide context and overall in the exome.

Table S7 (separate file)

Sanger sequencing results of TMZ-associated mutations.