Supplementary Materials

Health and population effects of rare gene knockouts in adult humans with related parents

Vagheesh M. Narasimhan, Karen A. Hunt, Dan Mason, Christopher L. Baker, Konrad J. Karczewski, Michael R. Barnes, Anthony H. Barnett, Chris Bates, Srikanth Bellary, Nicholas A. Bockett, Kristina Giorda, Christopher J. Griffiths, Harry Hemingway, Zhilong Jia, M. Ann Kelly, Hajrah A. Khawaja, Monkol Lek, Shane McCarthy, Rosie McEachan, Anne O'Donnell-Luria, Kenneth Paigen, Constantinos A. Parisinos, Eamonn Sheridan, Laura Southgate, Louise Tee, Mark Thomas, Yali Xue, Michael Schnall-Levin, Petko M. Petkov, Chris Tyler-Smith, Eamonn R. Maher, Richard C. Trembath, Daniel G. MacArthur, John Wright, Richard Durbin, David A. van Heel

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S8
  • Tables S1 to S8
  • Captions for Data S1 to S3
  • Full Reference List
Data S1
List of genes containing high confidence rhLOF genotypes, along with transcript specific annotation and numbers of heterozygote and homozygote genotypes in 3,222 individuals.
Data S2
Overlap of genes with homozygous LoFs across 3,222 British Pakistanis, 104,220 Icelanders, and 60,706 individuals in the ExAC dataset.
Data S3
Meiotic recombination crossover locations between mother and child for NA12878 duo as determined by pedigree and molecular phasing, along with crossover locations for PRDM9 duo.