Supplementary Materials

Negative selection in humans and fruit flies involves synergistic epistasis

Mashaal Sohail, Olga A. Vakhrusheva, Jae Hoon Sul, Sara L. Pulit, Laurent C. Francioli, Genome of the Netherlands Consortium, Alzheimer’s Disease Neuroimaging Initiative, Leonard H. van den Berg, Jan H. Veldink, Paul I. W. de Bakker, Georgii A. Bazykin, Alexey S. Kondrashov, Shamil R. Su

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S18
  • Tables S1 to S22
  • Consortia
  • References
Table S1
A tab-delineated file containing all supplementary tables that did not fit into the supplementary materials file.
Data S1
A tab-delineated file containing DatafileS1 (a complete list of all candidate LoF singletons in six human data sets that were used for mutation burden analysis), DatafileS2 (a complete list of all samples in Drosophila Population Genomics Project (DPGP3) and The Drosophila Genetic Reference Panel (DGRP) with additional annotation), and DatafileS3 (a complete list of all candidate rare LoF variants with minor allele count ≤ 5 in two fruit fly datasets that were used for mutation burden analysis).