Supplementary Materials

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils

Camilla Engblom, Christina Pfirschke, Rapolas Zilionis, Janaina da Silva Martins, Stijn A. Bos, Gabriel Courties, Steffen Rickelt, Nicolas Severe, Ninib Baryawno, Julien Faget, Virginia Savova, David Zemmour, Jaclyn Kline, Marie Siwicki, Christopher Garris, Ferdinando Pucci, Hsin-Wei Liao, Yi-Jang Lin, Andita Newton, Omar K. Yaghi, Yoshiko Iwamoto, Benoit Tricot, Gregory R. Wojtkiewicz, Matthias Nahrendorf, Virna Cortez-Retamozo, Etienne Meylan, Richard O. Hynes, Marie Demay, Allon Klein, Miriam A. Bredella, David T. Scadden, Ralph Weissleder, Mikael J. Pittet

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Figs. S1 to S23
  • Table S1
  • References
Table S3
SiglecF correlated and anti-correlated genes
Tabel S4
Differentially expressed genes between T-SiglecFhigh, T-SiglecFlow and H-SiglecFlow cells.
Table S5
Gene expression data for T-SiglecFhigh, T-SiglecFlow and H-SiglecFlow neutrophils (used to generate Fig. 5b and S19d).
Table S6
Human orthologs for murine SiglecF correlated genes used to generate human T-SiglecFhigh and TSiglecFlow neutrophil gene signature
Table S7
Patient demographics included in Cox regression analysis
Table S8
Cox regression analysis of T-SiglecFhigh and T-SiglecFlow neutrophil gene signature and patient outcome.

Additional Data

Table S2
Neutrophil single-cell RNA-Seq TPM (transcripts per million) data.