Supplementary Materials

Detection and localization of surgically resectable cancers with a multianalyte blood test

Joshua D. Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A. Javed, Fay Wong, Austin Mattox, Ralph. H. Hruban, Christopher L. Wolfgang, Michael G. Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P. Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T. Vogelstein, James D. Browne, Robert E. Schoen, Randall E. Brand, Jeanne Tie, Peter Gibbs, Hui-Li Wong, Aaron S. Mansfield, Jin Jen, Samir M. Hanash, Massimo Falconi, Peter J. Allen, Shibin Zhou, Chetan Bettegowda, Luis Diaz, Cristian Tomasetti, Kenneth W. Kinzler, Bert Vogelstein, Anne Marie Lennon, Nickolas Papadopoulos

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Material and Methods
  • Figs. S1 to S4
  • References
Tables S1 to S11
Table S1: Primer sequences for multiplex PCR assays.
Table S2: Mutations identified in primary tumors.
Table S3: Protein biomarkers analyzed and included in CancerSEEK test.
Table S4: Histopathological and clinical characteristics of the cancer patients and healthy controls.
Table S5: Mutations identified in plasma samples from cancer patients and healthy controls.
Table S6: Concentrations of assayed protein biomarker in plasma samples from cancer patients and healthy controls.
Table S7: Concordance between mutations identified in the plasma with those identified in primary tumors.
Table S8: Cancer type localization results for the 617 cancer patients identified by CancerSEEK.
Table S9: Logistic regression model coefficients and importance scores.
Table S10: Confusion matrix of top predictions from cancer type localization results.
Table S11: Cancer patients evaluated in this study by tumor type and stage.