Supplementary Materials

Ultrapotent chemogenetics for research and potential clinical applications

Christopher J. Magnus, Peter H. Lee, Jordi Bonaventura, Roland Zemla, Juan L. Gomez, Melissa H. Ramirez, Xing Hu, Adriana Galvan, Jayeeta Basu, Michael Michaelides, Scott M. Sternson

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S11
  • Tables S1 to S6
  • Captions for Movies S1 and S2
  • References

Images, Video, and Other Media

Movie S1
Rotation response to unilateral SNr silencing after intraperitoneal administration of saline (left) or varenicline (right, 0.1 mg/kg). Comparison of the same mouse expressing PSAM4-GlyR—IRES—EGFP unilaterally in the right SNr at 50 min post-injection.
Movie S2
Rotation response to unilateral SNr silencing after intraperitoneal administration of uPSEMs and varenicline. Comparison of the same mouse expressing PSAM4-GlyR—IRES—EGFP unilaterally in the left SNr at 60 min post-injection. A subthreshold dose of uPSEM793 is shown in the upper left panel.