Supplementary Materials

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

Silas Maniatis, Tarmo Äijö, Sanja Vickovic, Catherine Braine, Kristy Kang, Annelie Mollbrink, Delphine Fagegaltier, Žaneta Andrusivová, Sami Saarenpää, Gonzalo Saiz-Castro, Miguel Cuevas, Aaron Watters, Joakim Lundeberg†, Richard Bonneau†, Hemali Phatnani

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

Download Supplement
  • Materials and Methods
  • Figs. S1 to S16
  • Tables S1 and S10
  • Captions for Tables S2 to S9
  • References
Table S2
Table contains differential expression results of comparisons between regions per gene per time point. For instance, we compared expression per gene between ventral horn and dorsal horn, and ventral horn against all the other 11 AARs. Bayes factors and posterior means and standard deviations of compared β distributions are listed.
Table S3
Table contains differential expression results of comparisons between conditions per gene per time point. Bayes factors and posterior means and standard deviations of compared β distributions are listed.
Table S4
Genes comprising the modules illustrated in Fig. 3A are listed.
Table S5
Results of the analysis of enriched KEGG pathways among the genes comprising the modules depicted in Fig. 3A are listed. Only statistically significant KEGG pathways for each module are listed (one-tailed Fisher's exact test with Benjamini-Hochberg correction, FDR < 0.1).
Table S6
Results of the analysis of enriched KEGG pathways among the genes comprising the submodules are listed. Only statistically significant KEGG pathways for each module are listed (one-tailed Fisher's exact test with Benjamini-Hochberg correction, FDR < 0.1).
Table S7
The identified oligodendrocyte, astrocyte, and microglial submodules are listed. Additionally, the genes of the submodules are listed with expression levels.
Table S8
Genes comprising the modules illustrated in Fig. S10A are listed.
Table S9
Results of the analysis of enriched KEGG pathways among the genes comprising the modules depicted in Fig. 3A are listed. Only statistically significant KEGG pathways for each module are listed (one-tailed Fisher's exact test with Benjamini-Hochberg correction, FDR < 0.1).