Supplementary Materials

Oligogenic inheritance of a human heart disease involving a genetic modifier

Casey A. Gifford, Sanjeev S. Ranade, Ryan Samarakoon, Hazel T. Salunga, T. Yvanka de Soysa, Yu Huang, Ping Zhou, AryƩ Elfenbein, Stacia K. Wyman, Yen Kim Bui, Kimberly R. Cordes Metzler, Philip Ursell, Kathryn N. Ivey, Deepak Srivastava

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S5
  • Captions for Tables S1 to S8
  • Caption for Movies S1 to S3
  • References
Table S1
Exome analysis results.
Table S2
Primer, Cas9 guide RNA and donor template sequences.
Table S3
GO term results from differentially expressed genes in wild-type versus triple compound heterozygous mice.
Table S4
Statistically significant differentially expressed genes in wild-type vs triple compound heterozygous mice.
Table S5
GO term results from differentially expressed genes in day 8 hiPSC-derived cardiomyocytes from unaffected versus symptomatic LVNC cell lines.
Table S6
Statistically significant differentially expressed genes in day 8 hiPSC-derived cardiomyocytes from unaffected versus symptomatic LVNC cell lines.
Table S7
Genes differentially expressed in both human and mouse RNA sequencing datasets.
Table S8
ChIP-seq peak set used in figure 5.

Images, Video, and Other Media

Movie S1
Echocardiography of P4 wild-type mouse.
Movie S2
Echocardiography of P4 Mkl2Q664H/+ mouse.
Movie S3
Echocardiography of P4 Mkl2Q664H/Q664H mouse.