Supplementary Materials

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Keren Yizhak, François Aguet, Jaegil Kim, Julian M. Hess, Kirsten Kübler, Jonna Grimsby, Ruslana Frazer, Hailei Zhang, Nicholas J. Haradhvala, Daniel Rosebrock, Dimitri Livitz, Xiao Li, Eila Arich-Landkof, Noam Shoresh, Chip Stewart, Ayellet V. Segrè, Philip A. Branton, Paz Polak, Kristin G. Ardlie, Gad Getz

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S18
  • Captions for tables S1 to S15
  • References
Tables S1 to S15
Table S1. List of TCGA samples analyzed in this study
Table S2. Summary of the validation in normal (tumor-adjacent) samples
Table S3. List of somatic mutations detected in the GTEx dataset
Table S4. Summary of the Fluidigm assay results
Table S5. List of mutations found in normal tissues and their corresponding cancerous tissue
Table S6. List of somatic variants detected in the blood of healthy individuals
Table S7. Correlation and P value for the association between age\MKI67 expression levels and total number of mutations, while controlling for the number of tissues tested
Table S8. MKI67 expression levels across tissues
Table S9. List of cancer hotspot mutations
Table S10. List of cancer hotspot mutations detected in normal tissues
Table S11. List of cancer genes used in the analysis of identifying significantly mutated genes
Table S12. STAR and HiSat parameters used for alignment
Table S13. Hotspot mutations removed from the RNA Panel of Normals
Table S14. List of GTEx samples analyzed in this study
Table S15. List of genes and samples showing an allele-specific expression pattern