Supplementary Materials

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

Masahiro Hiraizumi, Keitaro Yamashita, Tomohiro Nishizawa, Osamu Nureki

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S16
  • Table S1
  • Caption for Movie S1
  • References

Images, Video, and Other Media

Movie S1
Entire phospholipid transport cycle of ATP8A1-CDC50a Schematic movie of the phospholipid translocation cycle by ATP8A1-CDC50a, according to the Post-Albers mechanism, with the morphed series of the conformational transitions through E1, E1- ATP, E1P-ADP, E1P, E2P, and E2Pi-PL. Each domain is illustrated with the same color code as in Fig. 1.