Supplementary Materials

Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions

Wenyan Han, Jun Li, Kenneth A. Pelkey, Saurabh Pandey, Xiumin Chen, Ya-Xian Wang, Kunwei Wu, Lihao Ge, Tianming Li, David Castellano, Chengyu Liu, Ling-Gang Wu, Ronald S. Petralia, Joseph W. Lynch, Chris J. McBain, Wei Lu

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

Download Supplement
  • Materials and Methods
  • Supplementary Text
  • Figs. S1 to S18
  • Captions for Movies S1 and S2
  • References

Images, Video, and Other Media

Movie S1
Vehicle. Mice were administrated with vehicle (i.p., 0.1 ml/10 g body weight), and the LORR latency and duration were tested. The behavior of a wild type (WT) mouse and a Shisa7 knockout (KO) mouse was recorded in the same screen. This video showed that both of Shisa7 WT and KO mice failed to exhibit LORR in 30 minutes, suggesting that vehicle did not induce LORR.
Movie S2
Diazepam (5 mg/ml, Hospira). Mice were administrated with diazepam (50 mg/kg, i.p., 0.1 ml/10 g body weight), and the LORR latency and duration were tested. The behavior of a WT mouse and a KO mouse were recorded in the same screen. The video showed that KO of Shisa7 prolonged LORR latency and reduced LORR duration compared to the WT mouse.