Supplementary Materials

Higher-fitness yeast genotypes are less robust to deleterious mutations

Milo S. Johnson, Alena Martsul, Sergey Kryazhimskiy, Michael M. Desai

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Supplementary Text
  • Figs. S1 to S12
  • Tables S1 to S6
  • Captions for Data Tables S1 to S3
  • References
Data Table S1
Inferred fitness effects for mutations in E1 and E2 along with mutation annotation information and the results of the modeling described in "Modeling genetic determinants of fitness effects," DFE statistics from E1 and E2 along with the results of the modeling described in "Modeling genetic determinants of DFE statistics," inferred fitness effects for mutations during different stages of growth during the GC experiment, and cell density estimates and inferred growth rates for each segregant during the GC experiment.
Data Table S2
Inferred QTLs for individual mutations in E1, for individual mutations in E2, and for DFE statistics in E2 (No QTLs were detected for DFE statistics in E1), and information on multi-hit QTL regions including whether they were observed in previous work.
Data Table S3
Inferred fitness effects and significance testing results from our initial analysis of E1, which we used to choose mutations to include in E2.