Supplementary Materials

Huntington's disease alters human neurodevelopment

Monia Barnat, Mariacristina Capizzi, Esther Aparicio, Susana Boluda, Doris Wennagel, Radhia Kacher, Rayane Kassem, Sophie Lenoir, Fabienne Agasse, Barbara Y. Braz, Jeh-Ping Liu, Julien Ighil, Aude Tessier, Scott O. Zeitlin, Charles Duyckaerts, Marc Dommergues, Alexandra Durr, Sandrine Humbert

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S10
  • Table S1
  • Captions for Movies S1 to S8

Images, Video, and Other Media

Movie S1
Cdt1-mKO2 and GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ7/Q7 embryos (electroporated at E13.5). Frames were taken at 15 min intervals over periods of 10 hours (see frame images Fig. S9A).
Movie S2
Cdt1-mKO2 and Geminin-GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ7/Q7 embryos (electroporated at E13.5). Frames were taken at 10 min intervals over periods of 10 hours (see frame images Fig. S9B).
Movie S3
Cdt1-mKO2 and Geminin-GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ7/Q7 embryos (electroporated at E13.5). Frames were taken at 15 min intervals over periods of 9 hours (see frame images Fig. 3B, upper panel).
Movie S4
Cdt1-mKO2 and Geminin-GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ111/Q111 embryos (electroporated at E13.5). Frames were taken at 15 min intervals over periods of 9 hours (see frame images Fig. 3B, lower panel).
Movie S5
Geminin-GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ7/Q7 embryos (electroporated at E13.5). Frames were taken at 10 min intervals over periods of 4 hours (see frame images Fig. 3C, upper panel).
Movie S6
Geminin-GFP-expressing apical progenitors migrating in ventricular zone of cultured brain slices from E15.5 HdhQ111/Q111 embryos (electroporated at E13.5). Frames were taken at 10 min intervals over periods of 6 hours (see frame images Fig. 3C, lower panel).
Movie S7
Cdt1-mKO2 and Geminin-GFP-expressing apical progenitors in G1/S transition in ventricular zone of cultured brain slices from E15.5 HdhQ7/Q7 embryos (electroporated at E13.5). Frames were taken at 15 min intervals over periods of 5 hours (see frame images Fig. 3D, upper panel).
Movie S8
Cdt1-mKO2 and Geminin-GFP-expressing apical progenitors in G1/S transition in ventricular zone of cultured brain slices from E15.5 HdhQ111/Q111 embryos (electroporated at E13.5). Frames were taken at 15 min intervals over periods of 3 hours (see frame images Fig. 3D, lower panel).