Supplementary Materials

Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase

Hai Zheng, Yilun Qi, Shibin Hu, Xuan Cao, Congling Xu, Zhinang Yin, Xizi Chen, Yan Li, Weida Liu, Jie Li, Jiawei Wang, Gang Wei, Kaiwei Liang, Fei Xavier Chen, Yanhui Xu

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Figs. S1 to S12
  • Table S1
  • Captions for Movies S1 to S7
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Images, Video, and Other Media

Movie S1
The 3.5-Å resolution cryo-EM map and model of the INTAC complex.
Movie S2
The combined cryo-EM map and model of the INTAC complex.
Movie S3
Cryo-EM map and model of the backbone module.
Movie S4
Cryo-EM map and model of the shoulder module.
Movie S5
Cryo-EM map and model of the phosphatase module.
Movie S6
Cryo-EM map and model around the shoulder-phosphatase contacts.
Movie S7
Cryo-EM map and model of the endonuclease module.
 
Correction (14 January 2021): Western blotting with PP2A-C antibody in fig. S7C (third row) was mistakenly placed during manuscript preparation by the authors. The corrected fig. S7C has been updated in the corrected version of the supplementary materials file. The conclusion of fig. S7C is that INTS11 shRNAs efficiently reduce the protein levels of INTS11 but not INTS8 or PP2A-C. Therefore, this correction does not affect any of the conclusions drawn in the paper.
The original version is accessible here.