Supplementary Materials

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

Christina V. Theodoris, Ping Zhou, Lei Liu, Yu Zhang, Tomohiro Nishino, Yu Huang, Aleksandra Kostina, Sanjeev S. Ranade, Casey A. Gifford, Vladimir Uspenskiy, Anna Malaschicheva, Sheng Ding, Deepak Srivastava

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S12
  • Captions for Data S1 to S5
  • References
Data S1
Targeted RNA-seq gene panel Gene transcripts measured in targeted RNA-seq experiments.
Data S2
Network-correcting molecule candidates identified by network-based small molecule screen Network-correcting molecule candidates identified by KNN and hierarchical clustering algorithms.
Data S3
Primary AV ECs Characteristics of patients from which primary AV ECs were derived.
Data S4
GO analysis of genes dysregulated in primary AV ECs GO analysis of genes dysregulated in primary cTAV and cBAV ECs by cluster.
Data S5
GO analysis of genes dysregulated in mouse AVs GO analysis of genes uniquely dysregulated in control-treated N1+/�/mTRG2 mice with AV disease (increased AV peak velocity, as opposed to N1+/�/mTRG2 mice with healthy AVs) compared to N1WT/mTRG2 mice.
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