Supplementary Materials

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Rory D. de Vries, Katharina S. Schmitz, Francesca T. Bovier, Camilla Predella, Jonathan Khao, Danny Noack, Bart L. Haagmans, Sander Herfst, Kyle N. Stearns, Jennifer Drew-Bear, Sudipta Biswas, Barry Rockx, Gaƫl McGill, N. Valerio Dorrello, Samuel H. Gellman, Christopher A. Alabi, Rik L. de Swart, Anne Moscona, Matteo Porotto

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S10
  • Table S1
  • Caption for Movie S1
  • References
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Images, Video, and Other Media

Movie S1
Proposed model of fusion inhibition by [SARSHRC-PEG4]2-chol. Proposed model of interactions between S on the viral envelope and Ace2 on the host cell membrane leading to membrane fusion. Side-by-side, Movie S1 shows proposed anchoring of the dimeric lipopeptide in the host cell membrane and interactions with the viral S protein to inhibit S-mediated fusion.