Supplementary Materials
Structure of the human Mediator-bound transcription preinitiation complex
R. Abdella, A. Talyzina, S. Chen, C. J. Inouye, R. Tjian, Y. He
Materials/Methods, Supplementary Text, Tables, Figures, and/or References
- Download Supplement
- Materials and Methods
- Supplementary Text
- Figs. S1 to S13
- Tables S1 and S2
- Caption for Movie S1
- References
- MDAR Reproducibility Checklist
Images, Video, and Other Media
- Movie S1
- Structure of the human Mediator-bound transcription pre-initiation complex.
- Movie S2
- 3D variability analysis of Med-PIC. Top three principal components (rows 1-3) shown of the front (left) and top (right) views of Med-PIC. Mediator and the CAK module of TFIIH largely move as a rigid body relative to the PIC.
- Movie S3
- 3D variability analysis of MedΔTail-PIC. Top three principal components (rows 1-3) shown of the front (left) and top (right) views of MedΔTail-PIC. MedHead, MedΔTail rotates relative to the PIC, and that movement can correlate with the movement of cTFIIH relative to the cPIC.
- Movie S4
- 3D variability analysis of Med-CAK. Top three principal components (rows 1-3) shown of the front (left) and top (right) views of Med-CAK. Mediator can flex, either causing lifting of MedHead and MedMiddle or bringing MedMiddle and MedTail closer together.