Supplementary Materials

Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT

Yiyang Jiang, Thomas L. Benz, Stephen B. Long

Materials/Methods, Supplementary Text, Tables, Figures, and/or References

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  • Materials and Methods
  • Figs. S1 to S16
  • Table S1
  • Caption for Movie S1
  • References
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Images, Video, and Other Media

Movie S1
Molecular dynamics simulation of HHAT in a lipid membrane. The depiction is as in fig. S10C, showing the heme (red sticks) in direct contact with lipid molecules. Lipid molecules are represented as semi-transparent sticks for their acyl chains and spheres for their phosphate moieties. Regions of HHAT that reside within the hydrophobic core of the membrane are colored cyan whereas solvent-exposed regions are magenta.