PT - JOURNAL ARTICLE AU - Kirshner, Norman AU - Sage, Harvey J. AU - Smith, W. James AU - Kirshner, Annette G. TI - Release of Catecholamines and Specific Protein from Adrenal Glands AID - 10.1126/science.154.3748.529 DP - 1966 Oct 28 TA - Science PG - 529--531 VI - 154 IP - 3748 4099 - http://science.sciencemag.org/content/154/3748/529.short 4100 - http://science.sciencemag.org/content/154/3748/529.full SO - Science1966 Oct 28; 154 AB - Rabbit antiserums directed against a purified protein obtained from the catecholamine storage vesicles of the adrenal medulla of the cow were used to study the mechanism of secretion from the adrenal medulla. During secretion evoked by acetylcholine in isolated perfused adrenal glands, catecholamines and the specific intravesicular protein were released in relative amounts comparable to those present in the intact gland. Thus catecholamines are apparently released from the storage vesicles by a process resembling reverse pinocytosis.