PT  - JOURNAL ARTICLE
AU  - Reid, W. D.
AU  - Stefano, F. J. E.
AU  - Kurzepa, S.
AU  - Brodie, B. B.
TI  - Tricyclic Antidepressants: Evidence for an Intraneuronal Site of Action
AID  - 10.1126/science.164.3878.437
DP  - 1969 Apr 25
TA  - Science
PG  - 437--439
VI  - 164
IP  - 3878
4099  - http://science.sciencemag.org/content/164/3878/437.short
4100  - http://science.sciencemag.org/content/164/3878/437.full
SO  - Science1969 Apr 25; 164
AB  - Desipramine, a tricyclic antidepressant drug, almost completely prevents the accumulation of tritiated norepinephrine by sympathetic neurons of the rat heart after the injection of a tracer dose of the labeled amine. However, desipramine does not alter the accumulation of norepinephrine after the injection of a large dose of the neurohormone. Despite the failure of desipramine to block the neuronal uptake of norepinephrine, it still prevents exogenous norepinephrine from displacing the endogenous neurohormone (previously labeled with H3-norepinephrine) from intraneuronal storage sites.