PT  - JOURNAL ARTICLE
AU  - Viveros, O. H.
AU  - Arqueros, L.
AU  - Kirshner, N.
TI  - Quantal Secretion from Adrenal Medulla: All-or-None Release of Storage Vesicle Content
AID  - 10.1126/science.165.3896.911
DP  - 1969 Aug 29
TA  - Science
PG  - 911--913
VI  - 165
IP  - 3896
4099  - http://science.sciencemag.org/content/165/3896/911.short
4100  - http://science.sciencemag.org/content/165/3896/911.full
SO  - Science1969 Aug 29; 165
AB  - Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-β-hydroxylase activity and the catecholamine content of the storage vesicle fraction. After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-β-hydroxylase to catecholamine as did vesicles from untreated animals. These and other data indicate that neurogenic secretion from the adrenal medulla occurs by an all-or-none release from the storage vesicles.