PT  - JOURNAL ARTICLE
AU  - Clements, Rex S.
AU  - Morrison, Anthony D.
AU  - Winfgrad, Albert I.
TI  - Polyol Pathway in Aorta: Regulation by Hormones
AID  - 10.1126/science.166.3908.1007
DP  - 1969 Nov 21
TA  - Science
PG  - 1007--1008
VI  - 166
IP  - 3908
4099  - http://science.sciencemag.org/content/166/3908/1007.short
4100  - http://science.sciencemag.org/content/166/3908/1007.full
SO  - Science1969 Nov 21; 166
AB  - Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.