PT  - JOURNAL ARTICLE
AU  - Chan, Po Chuen
AU  - Goldman, Allan
AU  - Wynder, Ernest L.
TI  - Hydroxyurea: Suppression of Two-Stage Carcinogenesis in Mouse Skin
AID  - 10.1126/science.168.3927.130
DP  - 1970 Apr 03
TA  - Science
PG  - 130--132
VI  - 168
IP  - 3927
4099  - http://science.sciencemag.org/content/168/3927/130.short
4100  - http://science.sciencemag.org/content/168/3927/130.full
SO  - Science1970 Apr 03; 168
AB  - Hydroxyurea, a selective cytotoxic agent for cells in DNA synthesis, injected intraperitoneally at 24 and 48 hours after the first painting with 1 percent croton oil, significantly reduced the tumor yield in the two-stage chemical carcinlogenesis in mouse skin. A comparable group of mice receiving hydroxyurea only once at 24 hours had a tumor induction similar to that in controls.