RT Journal Article
SR Electronic
T1 Hydroxyurea: Suppression of Two-Stage Carcinogenesis in Mouse Skin
JF Science
JO Science
FD American Association for the Advancement of Science
SP 130
OP 132
DO 10.1126/science.168.3927.130
VO 168
IS 3927
A1 Chan, Po Chuen
A1 Goldman, Allan
A1 Wynder, Ernest L.
YR 1970
UL http://science.sciencemag.org/content/168/3927/130.abstract
AB Hydroxyurea, a selective cytotoxic agent for cells in DNA synthesis, injected intraperitoneally at 24 and 48 hours after the first painting with 1 percent croton oil, significantly reduced the tumor yield in the two-stage chemical carcinlogenesis in mouse skin. A comparable group of mice receiving hydroxyurea only once at 24 hours had a tumor induction similar to that in controls.