PT  - JOURNAL ARTICLE
AU  - Adams, J. G.
AU  - Winter, W. P.
AU  - Rucknagel, D. L.
AU  - Spencer, H. H.
TI  - Biosynthesis of Hemoglobin Ann Arbor: Evidence for Catabolic and Feedback Regulation
AID  - 10.1126/science.176.4042.1427
DP  - 1972 Jun 30
TA  - Science
PG  - 1427--1429
VI  - 176
IP  - 4042
4099  - http://science.sciencemag.org/content/176/4042/1427.short
4100  - http://science.sciencemag.org/content/176/4042/1427.full
SO  - Science1972 Jun 30; 176
AB  - Hemoglobin Ann Arbor, in which arginine replaces leucine in position 80 of the a chain, occurs in aflected individuals in low proportion to hemoglobin A. Biosynthetic studies were perforined on reticulocytes of a patient heterozygous for this hemoglobin. These studies suggested that the low percentage of hemoglobin Ann Arbor is prinlarily due to preferential destruction of the abnormal component. The reduced concentration of α Ann Arbor chains was also reflected in a decreased synthesis of normal β chains.