RT Journal Article
SR Electronic
T1 Biosynthesis of Hemoglobin Ann Arbor: Evidence for Catabolic and Feedback Regulation
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1427
OP 1429
DO 10.1126/science.176.4042.1427
VO 176
IS 4042
A1 Adams, J. G.
A1 Winter, W. P.
A1 Rucknagel, D. L.
A1 Spencer, H. H.
YR 1972
UL http://science.sciencemag.org/content/176/4042/1427.abstract
AB Hemoglobin Ann Arbor, in which arginine replaces leucine in position 80 of the a chain, occurs in aflected individuals in low proportion to hemoglobin A. Biosynthetic studies were perforined on reticulocytes of a patient heterozygous for this hemoglobin. These studies suggested that the low percentage of hemoglobin Ann Arbor is prinlarily due to preferential destruction of the abnormal component. The reduced concentration of α Ann Arbor chains was also reflected in a decreased synthesis of normal β chains.