RT Journal Article
SR Electronic
T1 Mixed Function Oxidase and Ethanol Metabolism in Perfused Rat Liver
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1435
OP 1437
DO 10.1126/science.176.4042.1435
VO 176
IS 4042
A1 Hassinen, Ilmo E.
A1 Ylikahri, Reino H.
YR 1972
UL http://science.sciencemag.org/content/176/4042/1435.abstract
AB Oxidation-reduction changes of cytochrome P-450 and oxygen consumption were measured in isolated perfused livers from normal and phenobarbital-treated rats. Phenobarbital treatment markedly increased the aminopyrine-induced reduction of cytochrome P-450, but ethanol did not cause any redox changes of this cytochrome. It was concluded that the microsomal ethanol-oxidizing system has an insignificant role in the metabolism of ethanol in intact liver.