PT - JOURNAL ARTICLE AU - Stutman, Osias TI - Tumor Development after 3-Methylcholanthrene in Immunologically Deficient Athymic-Nude Mice AID - 10.1126/science.183.4124.534 DP - 1974 Feb 08 TA - Science PG - 534--536 VI - 183 IP - 4124 4099 - http://science.sciencemag.org/content/183/4124/534.short 4100 - http://science.sciencemag.org/content/183/4124/534.full SO - Science1974 Feb 08; 183 AB - Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.