RT Journal Article
SR Electronic
T1 Skin Carcinogenesis: Cholesterol-5 α, 6 α-Epoxide Hydrase Activity in Mouse Skin Irradiated with Ultraviolet Light
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1216
OP 1217
DO 10.1126/science.186.4170.1216
VO 186
IS 4170
A1 Chan, Jarvis T.
A1 Black, Homer S.
YR 1974
UL http://science.sciencemag.org/content/186/4170/1216.abstract
AB Cholesterol-5α,6α-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5α,6α-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.