PT  - JOURNAL ARTICLE
AU  - Pattillo, RA
AU  - Hussa, RO
AU  - Story, MT
AU  - Ruckert, AC
AU  - Shalaby, MR
AU  - Mattingly, RF
TI  - Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line
AID  - 10.1126/science.867042
DP  - 1977 Jun 24
TA  - Science
PG  - 1456--1458
VI  - 196
IP  - 4297
4099  - http://science.sciencemag.org/content/196/4297/1456.short
4100  - http://science.sciencemag.org/content/196/4297/1456.full
SO  - Science1977 Jun 24; 196
AB  - Epidermoid cervical carcinoma cells (CaSki line) have been established in continuous culture. When leukocytes from cervical cancer patients were incubated with CaSki culture fluid concentrates, inhibition of leukocyte migration was observed in more than 70 percent of the patients tested. By contrast, significantly less inhibition was observed with normal donor leukocytes or leukocytes from patients with other types of cancer. These results were consistent with the expression of tumor-associated antigen by CaSki cells. Analysis of the serum from the donor of the cell line at the time of tumor biopsy, and of CaSki culture fluids, demonstrated the presence of the beta subunit of human chorionic gonadotropin.