PT  - JOURNAL ARTICLE
AU  - Chick, WL
AU  - Perna, JJ
AU  - Lauris, V
AU  - Low, D
AU  - Galletti, PM
AU  - Panol, G
AU  - Whittemore, AD
AU  - Like, AA
AU  - Colton, CK
AU  - Lysaght, MJ
TI  - Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats
AID  - 10.1126/science.407649
DP  - 1977 Aug 19
TA  - Science
PG  - 780--782
VI  - 197
IP  - 4305
4099  - http://science.sciencemag.org/content/197/4305/780.short
4100  - http://science.sciencemag.org/content/197/4305/780.full
SO  - Science1977 Aug 19; 197
AB  - An artificial pancreas consisting of beta cells cultured on synthetic semipermeable hollow fibers was tested in rats with alloxan-induced diabetes. When implanted ex vivo as arteriovenous shunts in the circulatory system these devices lowered concentrations of plasma glucose from 533 to between 110 and 130 milligrams per 100 milliliters, increased concentrations of plasma insulin, and restored intravenous glucose tolerance tests essentially to normal.