PT  - JOURNAL ARTICLE
AU  - Wolff, S
AU  - Rodin, B
TI  - Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells
AID  - 10.1126/science.644315
DP  - 1978 May 05
TA  - Science
PG  - 543--545
VI  - 200
IP  - 4341
4099  - http://science.sciencemag.org/content/200/4341/543.short
4100  - http://science.sciencemag.org/content/200/4341/543.full
SO  - Science1978 May 05; 200
AB  - Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.