PT  - JOURNAL ARTICLE
AU  - Margules, DL
AU  - Moisset, B
AU  - Lewis, MJ
AU  - Shibuya, H
AU  - Pert, CB
TI  - beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa)
AID  - 10.1126/science.715455
DP  - 1978 Dec 01
TA  - Science
PG  - 988--991
VI  - 202
IP  - 4371
4099  - http://science.sciencemag.org/content/202/4371/988.short
4100  - http://science.sciencemag.org/content/202/4371/988.full
SO  - Science1978 Dec 01; 202
AB  - Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.