PT  - JOURNAL ARTICLE
AU  - Alger, 
AU  - Sillerud, LO
AU  - Behar, KL
AU  - Gillies, RJ
AU  - Shulman, RG
AU  - Gordon, RE
AU  - Shae, D
AU  - Hanley, PE
TI  - In vivo carbon-13 nuclear magnetic resonance studies of mammals
AID  - 10.1126/science.7292005
DP  - 1981 Nov 06
TA  - Science
PG  - 660--662
VI  - 214
IP  - 4521
4099  - http://science.sciencemag.org/content/214/4521/660.short
4100  - http://science.sciencemag.org/content/214/4521/660.full
SO  - Science1981 Nov 06; 214
AB  - Natural abundance carbon-13 nuclear magnetic resonances (NMR) from human arm and rat tissues have been observed in vivo. These signals arise primarily from triglycerides in fatty tissue. Carbon-13 NMR was also used to follow, in a living rat, the conversion of C-1-labeled glucose, which was introduced into the stomach, to C-1-labeled liver glycogen. The carbon-13 sensitivity and resolution obtained shows that natural abundance carbon-13 NMR will be valuable in the study of disorders in fat metabolism, and that experiments with substrates labeled with carbon-13 can be used to study carbohydrate metabolism in vivo.