PT  - JOURNAL ARTICLE
AU  - Traub, RD
AU  - Wong, RK
TI  - Cellular mechanism of neuronal synchronization in epilepsy
AID  - 10.1126/science.7079735
DP  - 1982 May 14
TA  - Science
PG  - 745--747
VI  - 216
IP  - 4547
4099  - http://science.sciencemag.org/content/216/4547/745.short
4100  - http://science.sciencemag.org/content/216/4547/745.full
SO  - Science1982 May 14; 216
AB  - Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3. The model shows that this form of neuronal synchronization arises because of mutual excitation between neurons, each of which is capable of intrinsic bursting in response to a brief input.