PT  - JOURNAL ARTICLE
AU  - Feinberg, RN
AU  - Beebe, DC
TI  - Hyaluronate in vasculogenesis
AID  - 10.1126/science.6857242
DP  - 1983 Jun 10
TA  - Science
PG  - 1177--1179
VI  - 220
IP  - 4602
4099  - http://science.sciencemag.org/content/220/4602/1177.short
4100  - http://science.sciencemag.org/content/220/4602/1177.full
SO  - Science1983 Jun 10; 220
AB  - Limb buds of chicken embryos contain within the peripheral mesoderm an avascular zone that is rich in hyaluronic acid. Epithelial tissues that synthesize large amounts of hyaluronic acid relative to other glycosaminoglycans caused avascularity when implanted into normally vascular wing mesoderm. Epithelia that synthesize little hyaluronic acid did not cause avascularity. Elvax implants containing hyaluronic acid caused the formation of avascular zones, whereas similar implants containing other glycosaminoglycans did not give rise to avascular zones. Hyaluronic acid may thus play a role in determining the location of blood vessels in the embryo.