PT  - JOURNAL ARTICLE
AU  - Adams, ME
AU  - O'Shea, M
TI  - Peptide cotransmitter at a neuromuscular junction
AID  - 10.1126/science.6134339
DP  - 1983 Jul 15
TA  - Science
PG  - 286--289
VI  - 221
IP  - 4607
4099  - http://science.sciencemag.org/content/221/4607/286.short
4100  - http://science.sciencemag.org/content/221/4607/286.full
SO  - Science1983 Jul 15; 221
AB  - The neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) is present in the nerve terminals of an identified slow skeletal motoneuron in the cockroach. Proctolin is released onto the target muscle, a coxal depressor, by neuron stimulation and by depolarization with potassium. The physiological action of the motoneuron suggests that proctolin acts as a cotransmitter. Proctolin and neural stimulation produce delayed and sustained contractile effects without muscle depolarization.