RT Journal Article
SR Electronic
T1 Peptide cotransmitter at a neuromuscular junction
JF Science
JO Science
FD American Association for the Advancement of Science
SP 286
OP 289
DO 10.1126/science.6134339
VO 221
IS 4607
A1 Adams, ME
A1 O'Shea, M
YR 1983
UL http://science.sciencemag.org/content/221/4607/286.abstract
AB The neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) is present in the nerve terminals of an identified slow skeletal motoneuron in the cockroach. Proctolin is released onto the target muscle, a coxal depressor, by neuron stimulation and by depolarization with potassium. The physiological action of the motoneuron suggests that proctolin acts as a cotransmitter. Proctolin and neural stimulation produce delayed and sustained contractile effects without muscle depolarization.