PT  - JOURNAL ARTICLE
AU  - Shavit, Y
AU  - Lewis, JW
AU  - Terman, GW
AU  - Gale, RP
AU  - Liebeskind, JC
TI  - Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity
AID  - 10.1126/science.6691146
DP  - 1984 Jan 13
TA  - Science
PG  - 188--190
VI  - 223
IP  - 4632
4099  - http://science.sciencemag.org/content/223/4632/188.short
4100  - http://science.sciencemag.org/content/223/4632/188.full
SO  - Science1984 Jan 13; 223
AB  - The cytotoxic activity of natural killer cells was investigated in rats subjected to one of two inescapable footshock stress paradigms, both of which induce analgesia, but only one via activation of opioid mechanisms. Splenic natural killer cell activity was suppressed by the opioid, but not the nonopioid, form of stress. This suppression was blocked by the opioid antagonist naltrexone. Similar suppression of natural killer activity was induced by high doses of morphine. These results suggest that endogenous opioid peptides mediate the suppressive effect of certain forms of stress on natural killer cell cytotoxicity.